Inositol and PCOS
Inositols such as Myo- and D-chiro inositol are considered members of the B vitamin group, but in fact they are also carbohydrates with antioxidant properties. Inositol is found in many healthy natural foods, such as fruits, legumes, grains, and nuts, although our human bodies are also capable of making it.
Inositol and D-chiral inositol are involved in the regulation of insulin as secondary messengers of insulin secretion signaling, and they are thought to be deficient in the ability of inositol to be converted into chiral inositol within the body of women with PCOS, leading to insulin resistance and infertility.
Recent studies have shown that inositol supplementation is not only well tolerated, but has also been shown to improve insulin levels.
Inositols such as Myo- and D-chiro inositol are considered members of the B vitamin group, but in fact they are also carbohydrates with antioxidant properties. Inositol is found in many healthy natural foods, such as fruits, legumes, grains, and nuts, although our human bodies are also capable of making it.
Inositol and D-chiral inositol are involved in the regulation of insulin as secondary messengers of insulin secretion signaling, and they are thought to be deficient in the ability of inositol to be converted into chiral inositol within the body of women with PCOS, leading to insulin resistance and infertility.
Recent studies have shown that inositol supplementation is not only well tolerated, but has also been shown to improve insulin levels.
Binding Myo inositol and D-chiral inositol
New research into the effects of inositol shows that Myo is present in proportion to DCI in most tissues in the body. So inositol supplements are recommended to mix these two inositols, rather than use them alone.
Compared to inositol alone, women with PCOS had more benefits related to metabolic parameters when using a combination of inositol. While combined inositol use showed better results in weight loss, ovulation and pregnancy rates compared to metformin.
The ratio of inositol can affect egg quality and fertility
The ratio of myo-inositol to D-chiral inositol with an unbalanced physiological ratio in the body can affect the quality of the egg. Myo has been shown to improve egg quality in women with PCOS, while high doses (600-2400mg daily) of DCI have been found to negatively affect oocyte quality and ovarian reactivity. The more unbalanced the ratio of the two inositol, the worse the oocyte quality and ovarian response.
New research into the effects of inositol shows that Myo is present in proportion to DCI in most tissues in the body. So inositol supplements are recommended to mix these two inositols, rather than use them alone.
Compared to inositol alone, women with PCOS had more benefits related to metabolic parameters when using a combination of inositol. While combined inositol use showed better results in weight loss, ovulation and pregnancy rates compared to metformin.
The ratio of inositol can affect egg quality and fertility
The ratio of myo-inositol to D-chiral inositol with an unbalanced physiological ratio in the body can affect the quality of the egg. Myo has been shown to improve egg quality in women with PCOS, while high doses (600-2400mg daily) of DCI have been found to negatively affect oocyte quality and ovarian reactivity. The more unbalanced the ratio of the two inositol, the worse the oocyte quality and ovarian response.
Inositol and gestational diabetes mellitus
Studies have shown that inositol supplementation throughout pregnancy can effectively reduce the risk of gestational diabetes (GDM) in overweight women and women with PCOS. The gynecological endocrine study showed that the prevalence of GDM in pregnant women with PCOS in the inositol group was 17.4%, compared with 54% in the control group.
When trying to use a combination of inositol, use it only under medical guidance, and while using inositol supplements can be beneficial for improving PCOS, keep talking to your primary care provider.
Studies have shown that inositol supplementation throughout pregnancy can effectively reduce the risk of gestational diabetes (GDM) in overweight women and women with PCOS. The gynecological endocrine study showed that the prevalence of GDM in pregnant women with PCOS in the inositol group was 17.4%, compared with 54% in the control group.
When trying to use a combination of inositol, use it only under medical guidance, and while using inositol supplements can be beneficial for improving PCOS, keep talking to your primary care provider.
