Inositol and PCOS

Inositols such as Myo- and D-chiro-inositol are considered members of the B vitamin group, but they are actually carbohydrates with antioxidant properties. Inositol is found in many healthy natural foods such as fruits, beans, grains, and nuts, although our human bodies can also make it.

Inositol and D-chiro-inositol are involved in insulin regulation as secondary messengers of insulin secretion signaling, and they are thought to be defective in the ability of the body to convert myo-inositol to chiro-inositol in women with PCOS, leading to insulin resistance and insufficiency. nurture.

And recent research has shown that inositol supplementation is not only well tolerated, but has been shown to improve insulin levels.

Combines Myo-inositol and D-chiro-inositol

New research on the effects of inositol shows that Myo is present in proportion to DCI in most tissues in the body. So myo-inositol supplements recommend mixing the two inositols, rather than using them individually.

Compared with inositol alone, women with PCOS had more benefits related to metabolic parameters when using mixed inositol. And compared with metformin, mixed inositol use showed better results in terms of weight loss, ovulation and pregnancy rates.

Inositol ratio affects egg quality and fertility

The ratio of Myo-inositol to D-chiro-inositol, which is unbalanced in physiological ratios in vivo, affects egg quality. Myo has been shown to improve egg quality in women with PCOS, while high doses (600-2400mg daily) of DCI have been found to negatively impact oocyte quality and ovarian responsiveness. The more unbalanced the ratio of the two inositols, the worse the oocyte quality and ovarian response.

Inositol and gestational diabetes

Research has shown that inositol supplementation throughout pregnancy can effectively reduce the risk of gestational diabetes mellitus (GDM) in overweight women and women with PCOS. The Gynecological Endocrinology Study showed that the prevalence of GDM in PCOS pregnant women in the inositol group was 17.4%, compared with 54% in the control group.

When trying to use an inositol combination, please use it under medical guidance, and while using inositol supplements can be beneficial for improving PCOS, please maintain an ongoing conversation with your primary care physician.